ParkinsonCanadaV1, Main, Exploration, bibRecord, 004091

Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis

Identifieur interne : 004091 ( Main/Exploration ); précédent : 004090; suivant : 004092

Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis

Auteurs : C. S. Lee [Canada] ; M. Schulzer ; E. Mak ; J. P. Hammerstad ; S. Calne ; D. B. Calne

Source :

Neurology [ 0028-3878 ] ; 1995.

RBID : Pascal:95-0250273

Descripteurs français

Pascal (Inist)
- Extrapyramidal syndrome, Idiopathique, Asymétrie, Trouble fonctionnel, Pathogénie, Homme, Parkinsonisme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Adult, Age Factors, Aged, Aged, 80 and over, Asymmetry, Cross-Sectional Studies, Dysfunction, Extrapyramidal syndrome, Female, Functional Laterality (physiology), Human, Humans, Idiopathic, Middle Aged, Movement Disorders (physiopathology), Parkinson Disease (physiopathology), Parkinsonism, Pathogenesis.
MESH :
- physiology : Functional Laterality.
- physiopathology : Movement Disorders, Parkinson Disease.
- Adult, Age Factors, Aged, Aged, 80 and over, Cross-Sectional Studies, Female, Humans, Middle Aged.

Abstract

We investigated the asymmetry of focal deficits of bradykinesia in a cross-sectional study of 198 patients with idiopathic parkinsonism. We have analyzed the difference in Unified Parkinson's Disease Rating Scale (UPDRS) scores between the more and less affected sides in these patients, whose duration of symptoms ranged from 1 to 15 years. There was no significant change in the asymmetry or focality over this period; the deficit for each side progressed faster initially and then approached the normal age-related linear rate of decline. Previous studies indicate that there is an inverse linear relation between the UPDRS bradykinesia score and the nigral dopaminergic cell count. We infer that the rate of death of nigral dopaminergic neurons is predetermined from the time of onset of pathogenesis. The simplest explanation is that a causal event kills some cells and damages others so that they undergo premature death. This sequence of changes could be implemented through environmental (toxic or viral) damage to the genome. Several diverse sources of evidence support this concept

Affiliations:

Canada

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis</title>
<author><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, Vancouver hosp. health sci. cent., neurodegenerative disorders cent.</s1>
<s2>Vancouver BC</s2>
<s3>CAN</s3>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
</author>
<author><name sortKey="Hammerstad, J P" sort="Hammerstad, J P" uniqKey="Hammerstad J" first="J. P." last="Hammerstad">J. P. Hammerstad</name>
</author>
<author><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S." last="Calne">S. Calne</name>
</author>
<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">95-0250273</idno>
<date when="1995">1995</date>
<idno type="stanalyst">PASCAL 95-0250273 INIST</idno>
<idno type="RBID">Pascal:95-0250273</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000F73</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000F50</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000E57</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000E57</idno>
<idno type="wicri:doubleKey">0028-3878:1995:Lee C:patterns:of:asymmetry</idno>
<idno type="wicri:Area/Main/Merge">004814</idno>
<idno type="wicri:source">PubMed</idno>
<idno type="RBID">pubmed:7898691</idno>
<idno type="wicri:Area/PubMed/Corpus">001929</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001929</idno>
<idno type="wicri:Area/PubMed/Curation">001929</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001929</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001929</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001929</idno>
<idno type="wicri:Area/Ncbi/Merge">002424</idno>
<idno type="wicri:Area/Ncbi/Curation">002424</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">002424</idno>
<idno type="wicri:doubleKey">0028-3878:1995:Lee C:patterns:of:asymmetry</idno>
<idno type="wicri:Area/Main/Merge">004620</idno>
<idno type="wicri:Area/Main/Curation">004091</idno>
<idno type="wicri:Area/Main/Exploration">004091</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis</title>
<author><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, Vancouver hosp. health sci. cent., neurodegenerative disorders cent.</s1>
<s2>Vancouver BC</s2>
<s3>CAN</s3>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver BC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
</author>
<author><name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
</author>
<author><name sortKey="Hammerstad, J P" sort="Hammerstad, J P" uniqKey="Hammerstad J" first="J. P." last="Hammerstad">J. P. Hammerstad</name>
</author>
<author><name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S." last="Calne">S. Calne</name>
</author>
<author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="1995">1995</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Asymmetry</term>
<term>Cross-Sectional Studies</term>
<term>Dysfunction</term>
<term>Extrapyramidal syndrome</term>
<term>Female</term>
<term>Functional Laterality (physiology)</term>
<term>Human</term>
<term>Humans</term>
<term>Idiopathic</term>
<term>Middle Aged</term>
<term>Movement Disorders (physiopathology)</term>
<term>Parkinson Disease (physiopathology)</term>
<term>Parkinsonism</term>
<term>Pathogenesis</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Movement Disorders</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Cross-Sectional Studies</term>
<term>Female</term>
<term>Humans</term>
<term>Middle Aged</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Extrapyramidal syndrome</term>
<term>Idiopathique</term>
<term>Asymétrie</term>
<term>Trouble fonctionnel</term>
<term>Pathogénie</term>
<term>Homme</term>
<term>Parkinsonisme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">We investigated the asymmetry of focal deficits of bradykinesia in a cross-sectional study of 198 patients with idiopathic parkinsonism. We have analyzed the difference in Unified Parkinson's Disease Rating Scale (UPDRS) scores between the more and less affected sides in these patients, whose duration of symptoms ranged from 1 to 15 years. There was no significant change in the asymmetry or focality over this period; the deficit for each side progressed faster initially and then approached the normal age-related linear rate of decline. Previous studies indicate that there is an inverse linear relation between the UPDRS bradykinesia score and the nigral dopaminergic cell count. We infer that the rate of death of nigral dopaminergic neurons is predetermined from the time of onset of pathogenesis. The simplest explanation is that a causal event kills some cells and damages others so that they undergo premature death. This sequence of changes could be implemented through environmental (toxic or viral) damage to the genome. Several diverse sources of evidence support this concept</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><noCountry><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name>
<name sortKey="Calne, S" sort="Calne, S" uniqKey="Calne S" first="S." last="Calne">S. Calne</name>
<name sortKey="Hammerstad, J P" sort="Hammerstad, J P" uniqKey="Hammerstad J" first="J. P." last="Hammerstad">J. P. Hammerstad</name>
<name sortKey="Mak, E" sort="Mak, E" uniqKey="Mak E" first="E." last="Mak">E. Mak</name>
<name sortKey="Schulzer, M" sort="Schulzer, M" uniqKey="Schulzer M" first="M." last="Schulzer">M. Schulzer</name>
</noCountry>
<country name="Canada"><noRegion><name sortKey="Lee, C S" sort="Lee, C S" uniqKey="Lee C" first="C. S." last="Lee">C. S. Lee</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 004091 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 004091 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:95-0250273
   |texte=   Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis
}}

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis

Patterns of asymmetry do not change over the course of idiopathic parkinsonism : implications for pathogenesis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.